Easy Homemade Chicken Pot Pie Casserole Recipe

Highlighted under: Comfort Food

Enjoy the comforting flavors of chicken pot pie in a simple casserole form that's perfect for weeknight dinners.

Lucy Bennett

Created by

Lucy Bennett

Last updated on 2025-12-11T12:07:44.534Z

This Easy Homemade Chicken Pot Pie Casserole Recipe is a family favorite that brings warmth and comfort to the table. With tender chicken, vegetables, and a creamy sauce all topped with golden biscuits, it's a dish that everyone will love.

Why You'll Love This Recipe

  • A delightful mix of flavors and textures in every bite
  • Convenient one-dish meal that's easy to prepare
  • Perfect for leftovers or meal prep throughout the week

The Comfort of Home-Cooked Meals

There's nothing quite like the warmth and comfort of a homemade meal, especially on a busy weeknight. This Easy Homemade Chicken Pot Pie Casserole brings together all the classic flavors you love about chicken pot pie, but in a simplified, casserole format. It's a dish that not only satisfies the palate but also evokes feelings of nostalgia, making it a perfect choice for family dinners.

The combination of tender chicken, vibrant mixed vegetables, and creamy sauce creates a symphony of flavors that is sure to please everyone at the table. By using pre-cooked chicken and frozen vegetables, you can save time without sacrificing taste. This casserole is a great way to make the most of your kitchen staples while still delivering a hearty and satisfying meal.

Meal Prep Made Easy

One of the best aspects of this chicken pot pie casserole is its versatility. It’s ideal for meal prepping, allowing you to enjoy delicious, homemade dinners throughout the week. Simply prepare the casserole ahead of time and store it in the refrigerator. When you’re ready to eat, just pop it in the oven for a quick reheat. This makes it a fantastic option for busy families or anyone looking to streamline their weeknight cooking.

Additionally, this dish freezes well, so you can make a double batch and save one for later. Just be sure to cover it tightly before freezing. When you're ready to enjoy your frozen casserole, simply thaw it in the refrigerator overnight and bake as directed. This way, you’ll always have a comforting meal on hand, no matter how hectic your week gets.

Customizing Your Casserole

While this recipe offers a delicious base, one of the joys of cooking is making a dish your own. Feel free to customize your chicken pot pie casserole by adding your favorite ingredients. For instance, you can include herbs like thyme or rosemary for added flavor, or throw in some diced potatoes for extra heartiness. The possibilities are endless!

You can also switch up the type of protein used; turkey or even a meat alternative can work beautifully in this recipe. If you prefer a vegetarian option, simply replace the chicken with more vegetables or a protein substitute and use a cream of mushroom soup instead. This adaptability makes the casserole a favorite for a variety of dietary preferences.

Ingredients

For the casserole

  • 2 cups cooked chicken, shredded
  • 1 cup frozen mixed vegetables
  • 1 cup cream of chicken soup
  • 1/2 cup milk
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • Salt and pepper to taste

For the topping

  • 1 can refrigerated biscuit dough
  • 1 tablespoon butter, melted

Mix the ingredients well before assembling the casserole.

Instructions

Preheat the oven

Preheat your oven to 350°F (175°C).

Combine the filling

In a large bowl, combine the shredded chicken, mixed vegetables, cream of chicken soup, milk, garlic powder, onion powder, salt, and pepper.

Transfer to baking dish

Pour the mixture into a greased 9x13 inch baking dish.

Prepare the topping

Open the biscuit dough and cut each biscuit into quarters. Arrange the pieces evenly over the chicken mixture.

Bake

Brush the biscuits with melted butter and bake in the preheated oven for 30-35 minutes until the biscuits are golden brown and the filling is bubbly.

Serve

Allow to cool slightly before serving. Enjoy your delicious casserole!

Let the casserole sit for a few minutes before digging in to allow the filling to set.

Tips for Perfecting Your Casserole

To ensure the best results, make sure to season your filling well. Taste the mixture before pouring it into the baking dish, adjusting the seasoning as needed. This step is crucial for enhancing the overall flavor of your casserole. Remember that the biscuit topping will absorb some of the moisture, so a well-seasoned filling is key to achieving a balanced taste.

Also, consider using a combination of fresh and frozen vegetables for added texture and flavor. Fresh vegetables can introduce a lovely crunch, while frozen ones save time and ensure you always have the ingredients on hand. Just be sure to chop the fresh vegetables into small, uniform pieces for even cooking.

Serving Suggestions

This Easy Homemade Chicken Pot Pie Casserole is a complete meal on its own, but you can elevate the dining experience with a few simple sides. A light green salad dressed with a tangy vinaigrette pairs beautifully with the richness of the casserole, providing a refreshing contrast. You might also consider serving it with some crusty bread to soak up any delicious sauce left on the plate.

For a little extra indulgence, you can top each serving with a dollop of sour cream or a sprinkle of freshly chopped parsley. These garnishes not only add flavor but also make the dish visually appealing, perfect for impressing guests or making a family dinner feel a bit more special.

Secondary image

Questions About Recipes

→ Can I use leftover turkey instead of chicken?

Absolutely! Leftover turkey works wonderfully in this recipe.

→ Can I make this casserole ahead of time?

Yes! You can prepare the filling and top it with biscuits, then cover and refrigerate until ready to bake.

→ What vegetables can I add?

Feel free to add any vegetables you like, such as peas, corn, or carrots.

→ Is there a vegetarian version of this recipe?

Yes! Substitute the chicken with cooked lentils or chickpeas and use vegetable soup instead of cream of chicken soup.

Easy Homemade Chicken Pot Pie Casserole Recipe

Enjoy the comforting flavors of chicken pot pie in a simple casserole form that's perfect for weeknight dinners.

Prep Time20 minutes
Cooking Duration40 minutes
Overall Time60 minutes

Created by: Lucy Bennett

Recipe Type: Comfort Food

Skill Level: Easy

Final Quantity: 6 servings

What You'll Need

For the casserole

  1. 2 cups cooked chicken, shredded
  2. 1 cup frozen mixed vegetables
  3. 1 cup cream of chicken soup
  4. 1/2 cup milk
  5. 1 teaspoon garlic powder
  6. 1 teaspoon onion powder
  7. Salt and pepper to taste

For the topping

  1. 1 can refrigerated biscuit dough
  2. 1 tablespoon butter, melted

How-To Steps

Step 01

Preheat your oven to 350°F (175°C).

Step 02

In a large bowl, combine the shredded chicken, mixed vegetables, cream of chicken soup, milk, garlic powder, onion powder, salt, and pepper.

Step 03

Pour the mixture into a greased 9x13 inch baking dish.

Step 04

Open the biscuit dough and cut each biscuit into quarters. Arrange the pieces evenly over the chicken mixture.

Step 05

Brush the biscuits with melted butter and bake in the preheated oven for 30-35 minutes until the biscuits are golden brown and the filling is bubbly.

Step 06

Allow to cool slightly before serving. Enjoy your delicious casserole!

Nutritional Breakdown (Per Serving)

  • Calories: 380 kcal
  • Total Fat: 26g
  • Saturated Fat: 15g
  • Cholesterol: 195mg
  • Sodium: 85mg
  • Total Carbohydrates: 32g
  • Dietary Fiber: 3g
  • Sugars: 4g
  • Protein: 6g